Monday, November 28, 2011

When fitness takes a happy holiday (Reuters)

NEW YORK (Reuters) ? It's the season when yoga classes are canceled and gyms go on holiday schedules, so to avoid the fitness consequences of all those Christmas parties, experts suggest making a workout plan and sticking to it.

"I tell my clients to make sure they have a routine in their back pocket," said Colorado-based fitness instructor Stacey Lei Krauss, "something equipment-free that can be done in a small space, especially if you don't have easy access to a gym over the holidays."

Krauss, who created a fitness DVD called "Willpower and Grace," said those are qualities we're apt to abandon to family and friends during the holiday season.

"It's expected. It's family time; but giving back to yourself is just as important," she said. "Will power leads to self-confidence. Will power is self-control: the ability to manage yourself, regardless of what's happening around you. "

So when Krauss goes home for the holidays, she'll stick to her morning run and skip the big family breakfast.

"My mother will say, 'Oh, do you need to work out now?' I'll say, 'Yes,'" she explained. "We need to stay on track with what works for us."

Connecticut-based exercise instructor Ellen Barrett's yoga-based classes stress the mind-body connection.

During the holidays mental fatigue can weigh you down as surely as that extra cup of egg nog, she believes, but strengthening the spirit may be as simple as downing a glass of water.

"Drink a lot of water. It carries oxygen that will keep you alert, so emotional fatigue won't set in as quickly," she said.

And get moving in the morning.

"Do something. Take a 20 minute walk, even if its pitch black outside," she advised.

Even if the exigencies of family and season annihilate the best workout intentions, Barrett said it is still possible to pursue a healthy lifestyle.

"Don't think exercise is the only way to stay well," she said. "Do a salt scrub, or hit the juice bar for a couple of shots of wheat grass. You'll feel good and you'll have gotten your veggies."

To counterbalance seasonal excess, Jessica Matthews, spokesperson for the American Council on Exercise (ACE), advocates moderation.

"Shift your mindset from that all-or-nothing mentality," said Matthews, an exercise physiologist based in San Diego, California.

"We actually measured muscle activity to find the most effective exercises," she said.

The lunges, squats, crunches and extensions target those problem areas of the butt (glutes), the core (abdominals), and the upper arms (triceps).

At 84 years old, fitness instructor Ann Smith, creator of the DVD "Stretching for Seniors," said she mainly advises her holiday-stressed clients to relax and have a good time.

"Trust yourself. Trust your instincts," said Smith, whose training and love of dance she learned from her mother, an interpretive artist of the Isadora Duncan period.

"All you need is to eat, sleep and move every day," Smith said. "Walk. Scrub the floor. And if you can't think of anything to do, then start singing. Singing is good exercise."

Source: http://us.rd.yahoo.com/dailynews/rss/oddlyenough/*http%3A//news.yahoo.com/s/nm/20111128/od_nm/us_fitness_holiday

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Egypt protesters clash with police, one dead (Reuters)

CAIRO (Reuters) ? Protesters demanding an end to army rule clashed with police firing tear gas near Egypt's parliament building on Saturday in a flare-up that cast another shadow over a parliamentary election billed as the nation's first free vote in decades.

Protesters said one man, Ahmed Sayed, 21, died after being hit by a state security vehicle. His death was the first since a truce between police and demonstrators on Thursday calmed violence that had killed 41 people in Cairo and elsewhere.

Egypt's Interior Ministry said the vehicle had hit him by accident.

Hundreds of demonstrators camped overnight in Cairo's Tahrir Square ahead of the election, due to start on Monday in Cairo, Alexandria and some other areas.

The clash occurred after one group marched to parliament to protest against the army's appointment of 78-year-old Kamal Ganzouri, a premier under Hosni Mubarak, as new prime minister.

"Down, down with the marshal," a group chanted in the square, near tents set up on grassy patches. They were referring to Field Marshal Mohamed Hussein Tantawi, who heads the ruling army council and was Mubarak's defense minister for 20 years.

The military council said on Friday each stage of voting would be held over two days instead of one to give everyone the chance to vote. Voting starts on Monday but will not end until early January because of the election's various stages.

Tahrir protesters have dismissed Ganzouri, premier from 1996 to 1999, as another face from the past whose appointment reflects the generals' resistance to change.

"Why are they picking Ganzouri now? This shows that the army is unwilling to let go of any power by recycling a former ally. This government won't have any powers, why else pick someone that is loyal to them?" asked protester Mohamed El Meligy, 20.

Tens of thousands gathered on Friday to demand that the army council leave power now to accelerate a transition to democracy.

Alarmed by the violence, The United States and the European Union have urged a swift handover to civilian rule in a country where prolonged political turmoil has compounded economic woes.

The generals have resisted calls to quit now. Instead, they have promised that a new president will be elected by mid-2012, sooner than previously announced, and on Friday named Ganzouri to head a "national salvation government."

Ganzouri described his task as thankless and "extremely difficult," saying his priority was to secure the streets and revive the economy. Egypt's pound has hit a seven-year low and foreign reserves have dropped by a third since December 2010.

DIVIDE

While tens of thousands packed Tahrir Square for what activists dubbed "Last Chance Friday," at least 5,000 people demonstrated in support of the army in another Cairo square, highlighting splits between youngsters bent on radical reform and more cautious Egyptians keen to restore normality.

Ganzouri's appointment has reinforced that divide.

"He is a very good man, he did a lot of good things. If he had continued in his role (in 1999) the situation would have been much better," said restaurant worker Osama Amara, 22.

Protest groups have put forward their own demands for a government they want to be headed by presidential candidate and former U.N. nuclear watchdog chief Mohamed ElBaradei.

They have also called for another mass rally on Sunday to press demands for an immediate transfer of power from the military to a civilian national salvation government.

In Tahrir, shunned by main political groups such as the Muslim Brotherhood's Freedom and Justice Party this week, some protesters said the vote should be delayed.

The Brotherhood, Egypt's best organized political force, wants the election to go ahead as scheduled.

"Believe me, I don't know who I am going to vote for," said Hoda Ragab, a 55-year-old woman at Friday's protest in Tahrir, adding that elections should be postponed until calm returned.

(Additional reporting by Mohamed Abdellah, Marwa Awad and Reuters Television; Writing by Alistair Lyon)

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/nm/20111126/ts_nm/us_egypt_protests

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Video: Prince William saves the day



LESTER HOLT, anchor: Also taking to the skies today, Lieutenant William Wales , better known to you and me as Prince William . He's not just second in line to the British throne , he's also an officer with the British Royal Air Force , and today he was a man on a mission , a life saving mission. We get the story tonight from NBC 's Annabel Roberts .

ANNABEL ROBERTS reporting: Early this morning in the cold waters of the Irish Sea , a man waved frantically from a life raft. An RFC seeking helicopter had been sent to rescue him. The co-pilot, the future king of England himself, Prince William . The eight-man crew of the cargo ship Swanland had been sailing along the west coast of Britain in atrocious weather.

Mr. RAY CARSON (Her Majesty's Coast Guard): She was hit by what he described as an enormous wave. She rolled, broke her back and obviously was such a

catastrophic......it sank very quickly.

ROBERTS: First one survivor and then a second were plucked from the life raft. One member of the crew was found dead, five are still missing. On board the helicopter, the survivors found themselves beside the heir to the British throne , Prince William , who flew them to safety. In April , the queen visited the base in Wales where William is spending three years as a Royal Air Force search and rescue pilot. His brother, Prince Harry , has also faced danger. While serving in Afghanistan , he carried out patrols in hostile areas and says he's keen to return.

Mr. ROBERT JOBSON (NBC Royal Contributor): Prince William has always said that when he became a servicemen, he wanted to have a proper job. There's no way he could be posted like his brother Prince Harry to the front line in Afghanistan because of his role as the future king, but he is a serviceman. He's not going to shirk his responsibilities.

ROBERTS: William and his new bride Kate Middleton live a relatively normal life in rural north Wales , not from far from William 's base. But early next year the newlyweds will be separated when William is deployed to the remote Falkland Islands in the South Atlantic , Kate 's first taste of the typical life of a military wife. This rescue was the prince's most harrowing mission to date, but no doubt there will be more like this as the future king spreads his wings. Annabel Roberts, NBC News, London.

Source: http://video.msnbc.msn.com/nightly-news/45454711/

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6 players killed in Togolese team bus crash

By EBOW GODWIN

updated 6:13 p.m. ET Nov. 26, 2011

LOME, Togo - At least six topflight Togolese soccer players were killed and another 28 people critically injured on Saturday after a bus carrying their team plunged into a ravine and caught fire.

In a statement read on national television, the Togo government said President Faure Gnassingbe had ordered that those injured from the Etoile Filante club be taken to the military wing of the Lome Central Hospital to receive urgent medical attention.

A delegation, led by sports minister Christophe Tchao, traveled to the accident site with an ambulance to evacuate the injured.

The accident happened near the city of Atakpame, about 160 kilometers (100 miles) north of Lome, as Etoile Filante was on its way to Togo's second largest city of Sokode for Sunday's league game against Semassi.

A tire is believed to have burst, causing the bus to topple over and plunge down a ravine. Some of the victims reportedly burnt to death. Eyewitness accounts said the bus flipped over several times as it crashed into the ravine.

"We do not know how we managed to get out of the accident," said one of the survivors, goalkeeper Mama Souleyman.

Images on Togo national television showed the smoldering wreckage of the bus, which was almost completely burnt to ashes.

Lome-based Etoile Filante is a seven-time Togo national league champion and was runner-up in Africa's continental club competition in 1968.

Last year, two Togo national team officials were killed and several players hurt after a gun attack on the team's bus as it traveled to the African Cup of Nations tournament in Angola.

In 2007, Togo sports minister Richard Attipoe was among 22 people who died when a helicopter carrying Togolese soccer fans and officials crashed in Sierra Leone after an African Cup qualifying match.

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Speed's death casts pall

The death of Wales manager Scott Speed cast a shadow over the English Premier League games on Sunday.

Source: http://nbcsports.msnbc.com/id/45446882/ns/sports-soccer/

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Sunday, November 27, 2011

MIT slinks into a cafe, orders a side of photonic chips on silicon

Whiz-kids the world over have been making significant progress on the development of photonic chips -- devices that "use light beams instead of electrons to carry out their computational tasks." But now, MIT has taken the next major leap, filling in "a crucial piece of the puzzle" that just might allow for the creation of photonic chips on the standard silicon material that underlies most of today's electronics. Today, data can travel via light beams shot over through optical fibers, and once it arrives, it's "converted into electronic form, processed through electronic circuits and then converted back to light using a laser." What a waste. If MIT's research bears fruit, the resulting product could nix those extra steps, allowing the light signal to be processed directly. Caroline Ross, the Toyota Professor of Materials Science and Engineering at MIT, calls it a diode for light; to construct it, researchers had to locate a material that was both transparent and magnetic. In other words, a material that only exists in the Chamber of Secrets. Hit the source link for the rest of the tale.

MIT slinks into a cafe, orders a side of photonic chips on silicon originally appeared on Engadget on Fri, 25 Nov 2011 11:16:00 EDT. Please see our terms for use of feeds.

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Food We Eat Might Control Our Genes

Advances | Health Cover Image: December 2011 Scientific American MagazineSee Inside

Scientists find rice microRNA inside human cells


Image: Busse Yankushev Alamy

?You are what you eat.? The old adage has for decades weighed on the minds of consumers who fret over responsible food choices. Yet what if it was literally true? What if material from our food actually made its way into the innermost control centers of our cells, taking charge of fundamental gene expression?

That is in fact what happens, according to a recent study of plant-animal micro?RNA transfer led by Chen-Yu Zhang of Nanjing University in China. MicroRNAs are short sequences of nucleotides?the building blocks of genetic material. Although microRNAs do not code for proteins, they prevent specific genes from giving rise to the proteins they encode. Blood samples from 21 volunteers were tested for the presence of microRNAs from crop plants, such as rice, wheat, potatoes and cabbage.

The results, published in the journal Cell Research, showed that the subjects? bloodstream contained approximately 30 different microRNAs from commonly eaten plants. It appears that they can also alter cell function: a specific rice microRNA was shown to bind to and inhibit the activity of receptors controlling the removal of LDL??bad? cholesterol?from the bloodstream. Like vitamins and minerals, microRNA may represent a previously unrecognized type of functional molecule obtained from food.

The revelation that plant microRNAs play a role in controlling human physiology highlights the fact that our bodies are highly integrated ecosystems. Zhang says the findings may also illuminate our understanding of co-evolution, a process in which genetic changes in one species trigger changes in another. For example, our ability to digest the lactose in milk after infancy arose after we domesticated cattle. Could the plants we cultivated have altered us as well? Zhang?s study is another reminder that nothing in nature exists in isolation.

Source: http://rss.sciam.com/click.phdo?i=cbe6c6fdb49fabb5a09f01a992a71666

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Car salesmen sell a dream to small-town India (AP)

BARABANKI, India ? Out on the edge of town, a few steps from the railroad tracks and across the street from an emerald-green field that stinks of sewage, Sanjeev Saxena sits inside a signpost of a new Indian era. Occasionally, he glances up from his desk to see if anyone is coming through the door.

He's waiting to sell you a dream.

It's a dream about small-town prestige, and air conditioning in the brutal north Indian summer. It's a dream they never thought they'd see in India's millions of villages, and of people who once couldn't imagine clawing their way into the middle class.

It's a dream that comes in 15 models and 35 colors. Financing is easily available.

"I remember when cars were for rich people," said Dharmendra Srivastava, 32, one of Saxena's seven salesmen at the brightly lit dealership with the unwieldy name Bright4Wheel. "Today, everyone in India wants to have a car: the city people, farmers, everyone."

___

Little is changing modern India more than the spread of cars, a four-wheeled reflection of its economic transformation and a window into the aspirations of the new Indian middle class.

The automotive metamorphosis has spread from the upper-class enclaves of India's biggest cities to its countless Barabankis: once-quiet towns now spilling over with concrete buildings, crowded streets and clattering vehicles.

Farmers and schoolteachers now buy cars. The Barabanki shopkeeper selling fluorescent tubes for 150 rupees ($3) apiece has one. The farmer-businessman with the one-room tire store has two.

Saxena, with his smoker's growl and graying comb-over, often tells his team that what they do is about sales technique: about confidence, about treating customers right, about knowing the latest offers.

"You need to learn how to convince people to buy. If you can't do that, you need to ask why," he told them during a recent sales meeting, his voice somewhere between an angry father's and an encouraging teacher's.

It was the first day of a string of autumn Hindu festivals marking the year's biggest shopping season, and an hour before the arrival of the day's first customers. It was three days before the Maruti-Suzuki dealership's monthly sales deadline. Everyone felt the pressure. "We can't lose a customer, no matter what happens," Saxena said.

But behind the technique is something else.

Maruti sells its cars with ads showing an idealized India that barely exists, even in the country's wealthiest enclaves: sprawling houses with white picket fences, highways with no traffic, friendly towns without a hint of litter. Everywhere, there are joyful Indians driving Marutis.

That's the Indian dream they're selling.

___

The fantasy began taking shape in 1991, when the government was facing crushing debt payments and dangerously low foreign exchange reserves. Desperate to save itself, India abandoned socialism and embraced globalization to become one of the world's fastest-growing economies.

Per capita income 20 years ago was $350, one-quarter of what it is today. The literacy rate was 42 percent. Cars were an unimaginable extravagance.

The small middle-class spent years on waiting lists for cars. Then, for the most part, they had two choices: the Ambassador, a ridiculously outdated bubble-topped sedan whose design was borrowed from 1950s Britain; and the Maruti 800, a stripped-down economy model that resembled a metal box with wheels.

What began in 1991, though, has turned India into an economic juggernaut, with a middle class now estimated at more than 250 million people. The country has paved more than 500,000 miles of roads in the past two decades, and car production and sales have skyrocketed. Maruti sells more cars than anyone else, but automakers from Mahindra to Ford to Hyundai have factories here. Customers can now buy anything from a $2,700 Tata Nano ? the dirt-cheap everyman's car that became a sales flop ? to a $712,000 Ferrari FF.

Indians bought 2.5 million cars last year, 25 percent more than the year before.

When sales here do suffer, as they have recently amid rising inflation and spiking interest rates, the results would still leave many Detroit auto executives sick with envy.

In the U.S., a bad year can mean car sales plummeting by more than 15 percent. In India, a bad year means growth of 2-4 percent.

Everywhere, cars are bringing change.

Mohammad Ismail came to Bright4Wheel on a recent afternoon from Kurkhila, his hometown about 20 miles away, for a minor repair.

"Five years ago, my village had just one car," he said. Then the first paved roads came, setting off a cascade of car-buying and more road-building, of friends buying cars to keep up socially with friends.

Ismail, a middle-school teacher who earns $600 a month, had never driven a car before last year. His elderly father, a retired government health worker, had never owned anything bigger than a motorcycle.

But six months ago, after a co-worker bought a car, Ismail decided it was time. His father gave $1,900 for the down payment, and Ismail arranged loan payments of $87 a month.

He brought home an $8,000 Maruti WagonR, a four-door hatchback.

"When I was a little kid, I dreamed that one day I would get to sit in a car," said Ismail, smiling broadly. "Even that seemed like a far-off dream."

___

The new India was made for Saxena's salesmen, connoisseurs of automotive consumerism.

There's Srivastava, who sells cars in his dreams, and Rohan, a quiet man with only one name who comes to life on the sales floor, shyness crumbling as he greets customers. There's Ashwini Gupta, who is saving up for his daughter's education, and Haris Rehman, a strutting 24-year-old with gel-spiked hair hoping to move to America.

There's Dinesh Kumar, a rail-thin 28-year-old who could pass for a teenager. Kumar was born in a nearby farming village, moved to Mumbai to sell ads for an Internet company, ran out of money, came home, and finally moved into a $20-a-month rented room. After three weeks at Bright4Wheel, he hasn't sold a car. He can spend an hour staring at his cellphone, hoping for a miracle buyer to call. Saxena has warned him: Make a sale or you'll be fired.

Misery engulfs him.

"There's a lot of pressure on me," he said, dazed. "I've been unlucky,"

Behind his back, the others suspect he won't make it.

"It's a pressure cooker, what we do," said Gupta, a friendly, twitchy man who seems incapable of sitting still. "Maybe if he had one sale he'd get some confidence. But he's too nervous."

To watch these men sell cars is to see a performance that combines a fierce faith in Maruti with a near-religious belief in the transforming power of cars. Mixed into that are the sales tactics you could find in most any American car lot.

At the Barabanki dealership they'll greet you with a firm, well-practiced handshake, look you in the eye and laugh at your jokes. There will be no talk of uncertain interest rates or market downturns as you look over the cars ? the paradise blue A-star, the beige Estilo ? and are eventually escorted to a faux-leather sofa for the final sales pitch.

It normally focuses on one issue: status.

"A man who sees his neighbor going out every night in his car gets frustrated. He says 'Dammit, I need a car too.'" said Gupta. "In villages, people used to buy land when they had money. But now, if you want to show you're successful you buy a sparkling new car and everyone comes to admire it."

These salesmen have helped transform India.

The cars they have sold have helped link thousands of long-isolated villages to cities and towns. Their cars have given people better access to jobs, schools and medical care. There are customers who talk about the schools their children can now attend and customers like Ismail, the teacher so proud of his WagonR, who says it saved his father's life.

When his father had a heart attack a few months ago, it was Ismail who rushed him to the nearest hospital. Kurkhila, like much of India, has no reliable emergency ambulance service.

"My father would have died without that car," he said.

But for every story like Ismail's, there is the other side of India's automotive miracle, from an explosion of traffic jams to choking pollution to ? by far ? the world's highest number of road fatalities - more than 200,000 a year.

This is a country where horn-honking is ubiquitous and turn signals are disdained. In most cities, someone with no driving experience can get a license with a $10 bribe.

By the middle of the 21st century, India is expected to have the world's largest population, and one of its largest economies. So what happens when hundreds of millions of Indians have cars?

Don't ask.

"I don't worry about traffic and such things," snorted Vikas Singh, a fast-talking finance broker who works down the street from Bright4Wheel, and who regularly arranges loans for its customers. "This is all money for me."

Then he laughed.

"At least two or three times a month someone comes to me and says 'I want a car ? today,'" he said, holding up his hands as if he was holding a bag of money. "And we get them a car that day."

___

Two decades of economic growth are rewriting India's cliches, with snake charmers and destitute holy men giving way to software millionaires and rich housewives trawling through air-conditioned malls.

In truth, both reflect the twin realities of modern India.

This is a country where Rolls Royce is expanding its presence, but where more than 400 million people still live without regular electricity.

It's a country where cars remain out of reach for most car salesmen, struggling near the bottom of India's middle class on salaries that seldom hit $500 a month, and are often much lower.

That's enough for schools for a salesman's children, and a new TV every few years. It's enough for a motorcycle. But it's not enough for a new car.

It's an irony that isn't lost in the Bright4Wheels showroom.

When would Srivastava buy a car? He looked down at the white tile floor.

"I'll get one in two years, maybe. Or four years, or five years," he said. But he needs money for schools, and is hoping to move his extended family ? nine people crowded into three rented rooms ? into a new house. His salary, normally about 10,000 rupees ($200) a month, is far more than his father earned as a lineman for the state electricity company.

But, he added: "There is just so much to buy today."

In many ways, the car salesmen of Barabanki are like the town itself.

For generations, Barabanki has been a hub for hundreds of nearby farming villages. Money came from trading agriculture produce, often menthol oil used in traditional medicines, or in selling cheap household goods to poor farming families.

Today, the choices for its residents have expanded immensely. Its outskirts now reach nearly to the suburbs of Lucknow, the ever-growing state capital about 30 kilometers (20 miles) away, and many townspeople commute to offices there. People who didn't finish high school insist their children go to college. People who speak no English make sure their children are fluent.

Meanwhile, some of those once-poor farmers have stumbled directly into the middle class, with incomes fed by rising food prices and skyrocketing land values. Today, lucky farmers can earn tens of thousands of dollars selling slivers of their fields to developers.

But while farmers can now walk into dealerships with sacks full of cash, this is still a town where bicycles far outnumber cars. And where successful car salesmen ride motorcycles home in the twilight.

___

When it becomes clear that a shopper is about to become a buyer, the salesmen say he is a "murga katega" ? a chicken about to be slaughtered. It's not meant as unkindly as it sounds.

Much to his own surprise, it's a phrase that Dinesh Kumar learned.

With the threat of dismissal looming, Kumar closed his first sale on Sept. 30. He did it by telling the customer his job was on the line, and that the customer would be revered in his neighborhood if he brought home a car.

The buyer signed.

Kumar has sold 10 cars since then.

In Barabanki, the chickens are no longer safe.

___

Associated Press Writer Biswajeet Banerjee contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111127/ap_on_bi_ge/as_india_selling_the_dream

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Saturday, November 26, 2011

UN rights official urges Maldives to stop flogging (AP)

COLOMBO, Sri Lanka ? The U.N. human rights chief urged the Maldives on Thursday to end the "degrading" practice of flogging women found to have had sex outside marriage.

"This practice constitutes one of the most inhumane and degrading forms of violence against women, and should have no place in the legal framework of a democratic country," U.N. High Commissioner for Human Rights Navi Pillay told Parliament.

"I strongly believe that a public debate is needed in Maldives on this issue of major concern," she said calling for law reforms against discrimination against women.

She told reporters later that she discussed with Maldives officials how to end the practice.

"At the very least, pending more permanent changes in the law, it should be possible for the government and the judiciary to engineer a practical moratorium on flogging," she said.

According to the law, 30 lashes are given to women found to have committed adultery. Court officials would not give numbers on how many women are flogged in the conservative Muslim nation, but the punishment is usually done in public.

Pillay also urged authorities to improve poor, exploitative conditions for migrant workers, especially those from Bangladesh.

"Migrant workers are often abused, exploited and cheated of their hard-earned income by traffickers and unscrupulous employers in the Maldives," she said.

She added it was the state's responsibility to protect workers who are vital to the tourism industry in the South Asian island nation known for picturesque beach resorts.

On her three-day visit to Maldives, Pillay has also expressed concern about rising religious intolerance. The country of 300,000 people forbids practicing religions other than Islam.

She now heads to Indonesia for meetings on human rights in Southeast Asian countries.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111124/ap_on_re_as/as_maldives_un

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91% The Descendants

All Critics (136) | Top Critics (41) | Fresh (124) | Rotten (12)

One of the year's best films, a bubbly meditation on family and responsibility that weighs just enough to matter.

With so many balls in the air the temptation is to rush from one plot strand to another, but Payne takes the opposite approach. He also captures the complexity of emotional reactions that grief stirs.

It's a lovely, heartfelt character study of common, everyday people trapped on the horns of an uncommon but not unheard-of dilemma.

The latest exhibit in Payne's careful dissection of the beached male, which runs from Matthew Broderick's character in "Election" to Jack Nicholson's in "About Schmidt" and Paul Giamatti's in "Sideways."

This mature, well-acted dramatic comedy is deeply satisfying, maybe even cathartic.

A tough, tender, observant, exquisitely nuanced portrait of mixed emotions at their most confounding and profound -- all at play within a deliciously damp, un-touristy Hawaii that's at once lush and lovely to look at.

It's smart, funny, heartbreaking, heartwarming, wise, and, despite some sad moments, genuinely optimistic. I experienced more feelings watching it than I usually get from ten movies.

Well-acted and touching with a mild eye for human foibles, this is one of the better-written films of the year.

What's so special about Payne's approach in The Descendants is how acutely observed and subtle the movie is, especially since the previews are selling it as a broader, more absurd comedy.

If you see The Descendants, see it for Clooney (and Woodley), but don't believe the hype that it's one for the ages.

A lot of The Descendants is affecting, but its mushier tone is often less emotionally resonant than the bitter sarcasm of Payne's earlier work.

This unforgettable movie succeeds by making audiences feel like a part of the family. Clooney knocks it out of the park with a marvelous performance. Woodley makes a strong bid for a supporting actress nomination. The supporting players are all given...

Here's where I am right now: The Descendants is the best movie of 2011. It is the movie of the year, in many ways beyond its simple superlative overall excellence.

(Clooney) is at the top of his game in his scenes alone with the comatose Elizabeth. Asking questions that are unable to be answered, his pain at his loss and her betrayal is heartbreaking.

Audiences will argue about whether it's a comedy or a drama, but they'll agree they saw a wonderful film.

The Descendants finds Payne, now 50, having arrived in midlife with a new maturity, eschewing solipsism and snickers for a deeper engagement with the world.

Clooney has never been better, displaying more range and less actor-ego than ever before... The Descendants would still be a splendid movie without him; with Clooney, it's one of 2011's very best.

It's good, but far less than you'd expect from the guy who started his career with the gleefully provocative Citizen Ruth and Election.

In the hands of writer-director Alexander Payne, Clooney has rarely seemed so much at home.

There are ample opportunities for the film to soak in pathos, righteousness, farce, or pictorialism, and Payne manages to nod at those pitfalls without falling into them.

An emotionally ennobling film that wears its compassion on the sleeve of its ugly Hawaiian print shirts.

Payne displays a knack for both perfect casting and using his lead actor in sometimes unconventional, unexpected ways

Director Alexander Payne prefers to start a movie with one strike against him. He always picks a dislikable protagonist... Then, as he slowly gives characters self-awareness, he gives us reasons to watch and care about them.

In playing an everyman stranded between anger and duty, Clooney earns an emotional payoff that a lesser actor would simply demand.

More Critic Reviews

Source: http://www.rottentomatoes.com/m/the_descendants_2011/

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EU to urge member states to accept Iranian exiles (AP)

BRUSSELS ? An official says the EU's foreign policy chief will urge the member countries to accept some of the Iranians living in a refugee settlement in Iraq.

Iraq's government has said it will close Camp Ashraf, where more than 3,000 Iranian exiles are living, by the end of the year. The U.N. says at least 34 people were killed when Iraqi security forces raided the camp in April.

The refugees, many of whom seek to overthrow Iran's clerical rulers, were taken in at the camp by Saddam Hussein's regime decades ago.

EU foreign policy chief Catherine Ashton will appeal to all 27 members of the bloc next week, asking countries to take in Ashraf residents with ties to them, the official, who spoke on condition of anonymity, said Thursday.

Others may return to Iran.

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/ap/20111124/ap_on_re_eu/eu_eu_iraq_camp_ashraf

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Investing in Valuable Metals Gold Bullion | All Stuff Ari

[unable to retrieve full-text content]Investing in Valuable Metals Gold Bullion. Posted on November 25, 2011 by. For the duration of these instances of financial hardship, there is a large demand for secure and reliable investments. Both knowledgeable and newbie investors are ...

Source: http://stuff-ari.com/2011/investing-in-valuable-metals-gold-bullion/

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Friday, November 25, 2011

Patent firm IPCom says to stop HTC German sales (Reuters)

(Reuters) ? German patent firm IPCom plans to halt as quickly as possible the sale of all HTC smartphones in Germany, another blow to the Taiwanese firm just two days after it shocked markets by cutting its fourth-quarter outlook.

IPCom said on Friday it would enforce an injunction based on a Mannheim court decision from February 2009 after HTC, the fourth largest smartphone vendor globally, withdrew its appeal, which was due to be decided on next week.

"IPCom now intends to execute this injunction in the shortest possible time," the company said in a statement.

"We will use the right awarded by the courts, likely resulting in HTC devices disappearing from shops during the crucial Christmas season."

No one at HTC was immediately available to comment.

"I wonder whether HTC will now pay up or somehow block the enforcement," said German patent expert Florian Mueller.

Germany is one of the largest smartphone markets in Europe.

"This represents an unwelcome distraction during an already difficult quarter for HTC," said CCS Insight analyst Geoff Blaber.

Late last month, HTC warned that revenue would fall by up to 8 percent in October-December from the third quarter, and this week it flagged a much bigger drop, citing tougher competition and the global downturn.

The stock has fallen 30 percent in eight straight trading days.

The popularity of Apple's iPhones and Samsung Electronics's Galaxy line-up, recession-weary shoppers and long-running lawsuits have taken the gloss off what was one of the industry's biggest success stories.

IPCom has battled for years against HTC and Nokia in European courts.

IPCom had acquired Bosch's mobile telephony patent portfolio, created between the mid-1980s and 2000, which includes about 160 patent families worldwide, including some of the key patents in the wireless industry, such as patent 100, which standardizes a cellphone's first connection to a network.

(Additional reporting by Christoph Steitz; Editing by Will Waterman)

Source: http://us.rd.yahoo.com/dailynews/rss/tech/*http%3A//news.yahoo.com/s/nm/20111125/tc_nm/us_htc_germany

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HBT: Players now must hide their smokeless tobacco

There are so many details of the new collective bargaining agreement spinning out this afternoon in various reports and tweets that it?s probably useful to have a link to a full outline of the new deal. ?Here is that outline, courtesy of MLB.com.

One of the interesting items: a nod to the recent push, signed on by U.S. Senators and public health officials, to have baseball ban smokeless tobacco use among players. ?But it was just a nod. It won?t be banned entirely, but baseball is wanting to get it out of sight as much as it can without actually taking it out of players? mouths:

Players, managers, and coaches will be prohibited from using smokeless tobacco during televised interviews and Club appearances. In addition, at any time when fans are permitted in the ballpark, players, managers and coaches must conceal tobacco products (including packages and tins), and may not carry tobacco products in their uniforms or on their bodies. Individuals who violate the policy will be subject to discipline. The parties also agreed upon an extensive program of education and public outreach regarding the dangers of smokeless tobacco.

So you can still dip, just don?t have the can in your back pocket. ?Which is basically the exact opposite of the rule from my high school in West Virginia. ?They didn?t enforce it that much though. ?I?ll be curious to see how much MLB enforces this new rule.

Source: http://hardballtalk.nbcsports.com/2011/11/22/the-new-cba-requires-players-to-hide-their-smokeless-tobacco/related

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Cholesterol-Lowering Drugs Safe for Long-Term Use, Study Finds (HealthDay)

TUESDAY, Nov. 22 (HealthDay News) -- British researchers have good news for anyone taking the cholesterol-lowering medications known as statins: These drugs are effective and safe, even when used for long periods of time, they say.

The 11-year study found that simvastatin (brand name Zocor) reduced the risk of cardiovascular disease by almost one-quarter. In addition, the researchers found no increase in illness or deaths from cancer or other non-vascular causes.

"All those at increased vascular risk should start taking statins early and continue taking them long term," said the study's lead author, Dr. Richard Bulbulia, a consultant vascular surgeon and research fellow in the clinical trial service unit at the University of Oxford in England.

"This will maximize the reductions in heart attacks, strokes and other vascular diseases, and is safe," said Bulbulia, who added that the study's findings should provide reassurance to physicians and their patients.

There are numerous other drugs in this class of medication, and Bulbulia said, "it seems reasonable to assume that [this study's findings] should hold true for other currently prescribed statins." Other commonly used statins include Lipitor, Crestor and Mevacor.

Results of the study are published in the Nov. 23 online issue of The Lancet. Funding for the study was provided by the U.K. Medical Research Council, the British Heart Foundation, Merck & Co. (manufacturer of Zocor) and Roche Vitamins.

The study looked at the long-term safety of simvastatin because some research suggested that the rates of some cancers and non-vascular health conditions were increased in people who had lower levels of LDL (bad) cholesterol.

Initially, the study recruited more than 20,500 people who had a high risk of heart disease and other cardiovascular problems for a trial of simvastatin versus a placebo. The study volunteers were between 40 and 80 years old.

Half the group was randomly assigned to take 40 milligrams of simvastatin daily, while the other half took a placebo. At the end of the treatment phase of the trial, which lasted about five years, study participants were encouraged to continue on their study treatment for as long as another six years. About 17,500 of the initial participants continued in the follow-up phase, according to the report.

People taking simvastatin reduced their "bad" cholesterol an average of 1 millimole per liter over five years. This reduction translated into a 23 percent drop in the risk of major cardiovascular events, such as heart attack and stroke, the researchers said. This benefit continued throughout the follow-up, reported the study.

When the researchers examined the data from the treatment and follow-up phases for evidence of any increases in non-vascular events, such as cancer, they found no significant differences between the two groups.

"Statin therapy appears safe, with no hazards, such as an excess risk of cancer or other major non-vascular morbidity or mortality emerging during the 11-year post-trial period," said Bulbulia.

Another expert praised statins' record.

"I think the statin drugs are an extraordinary class of medications, and a necessity in Western populations, where there is less physical exercise and more calorie consumption," said Dr. Howard Weintraub, clinical director of the Center for the Prevention of Cardiovascular Disease at NYU Langone Medical Center in New York City.

"These are very safe drugs, and this study demonstrates that safety, and that the vascular protection continues well beyond the termination of treatment," said Weintraub.

"I think the picture for cardiovascular disease would be very different if these drugs weren't a part of our armamentarium," he added.

More information

Learn more about statins from the U.S. Food and Drug Administration.

Source: http://us.rd.yahoo.com/dailynews/rss/meds/*http%3A//news.yahoo.com/s/hsn/20111123/hl_hsn/cholesterolloweringdrugssafeforlongtermusestudyfinds

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Thursday, November 24, 2011

Police: WA woman, 59, chases down purse snatcher

(AP) ? Police say a 59-year-old woman chased down a purse snatcher who was fleeing on a bicycle in Longview, Wash., pulled him to the ground and grabbed back her purse.

Two witnesses detained the man until officers arrived.

According to court documents filed this week, the purse snatch took place in a Safeway parking lot last Friday. The woman chased the bicyclist about 15 feet.

The purse contained $62 and five credit cards.

The Daily News reports that (http://bit.ly/sA5MtY) a Cowlitz County Superior Court judge found probable cause to charge 29-year-old Mark Grendahl Jr. of Longview with five counts of second-degree theft. The newspaper said he was held Wednesday evening in the Cowlitz County Jail on $25,000 bail.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/aa9398e6757a46fa93ed5dea7bd3729e/Article_2011-11-24-US-Purse-Snatch/id-0f417f457a4d44e89377d5377e3f1f54

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Apple opens doors to subscription gaming on iOS? | iLounge News

Apple is expanding its in-app subscription model to include game titles, according to a report from Bloomberg. Seattle-based game publisher Big Fish Games has received approval from Apple to offer users access to multiple game titles for a single recurring monthly fee. Dubbed Play Instantly, the subscription service will be offered through a single iOS app that will deliver unlimited access to a number of the company?s popular game titles streamed to the user?s device via Wi-Fi, allowing the player to easily switch between different games without having to download each title individually. Big Fish Games has also announced plans to offer a free, ad-supported version of the game service that will limit play to 30 minutes per day. Paid subscriptions are expected to initially cost $5 per month with an increase to $7 per month as more titles are added. The application and subscription service are initially available in the U.S. only. Big Fish Play Instantly is available from the U.S. App Store as a free download. [via Mac Rumors]

Update (5:00 EST): The application is no longer available on the App Store. No explanation has been given as to the reason for its disappearance.? We have reached out to the developer for comment and will update the story as more information becomes available.

Update (6:30 EST): According to another report from Bloomberg, Play Instantly was removed by Apple earlier today, after having been available on the App Store since November 18th. Paul Thelen, founder of Big Fish Games indicates that the company was ?notified [by Apple] that the app was removed,? and is ?trying to follow up with Apple to try to figure out what happened.?? Thelen indicated to Bloomberg that ?Apple had even signed off on a press release issued earlier today.? The Bloomberg report also notes that Tom Neumayr, an Apple spokesman, declined to comment.

Source: http://www.ilounge.com/index.php/news/comments/apple-opens-doors-to-subscription-gaming-on-ios/

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Top 20 Concert Tours from Pollstar (AP)

The Top 20 Concert Tours ranks artists by average box office gross per city and includes the average ticket price for shows in North America. The previous week's ranking is in parentheses. The list is based on data provided to the trade publication Pollstar by concert promoters and venue managers.

TOP 20 CONCERT TOURS

1. (1) Taylor Swift; $1,431,794; $70.02.

2. (2) Sade; $1,207,341; $88.60.

3. (3) Marc Anthony; $961,805; $84.29.

4. (4) Enrique Iglesias; $790,731; $66.74.

5. (6) Journey; $642,782; $55.18.

6. (5) Foo Fighters; $630,809; $48.09.

7. (7) Rascal Flatts; $517,925; $38.06.

8. (8) Jason Aldean; $517,258; $33.86.

9. (12) Keith Urban; $513,255; $58.29.

10. (11) Katy Perry; $505,190; $42.47.

11. (9) "American Idols Live"; $503,671; $55.79.

12. (10) Steely Dan; $483,169; $82.71.

13. (13) Def Leppard / Heart ; $475,559; $54.88.

14. (14) Train / Maroon 5; $435,119; $42.82.

15. (15) Selena Gomez & The Scene; $360,887; $40.23.

16. (16) Tiesto; $267,138; $44.65.

17. (18) Jeff Dunham; $235,817; $45.71.

18. (19) "So You Think You Can Dance"; $206,626; $53.92.

19. (20) Widespread Panic; $172,259; $37.83.

20. (New) Rain ? A Tribute To The Beatles; $165,126; $47.05.

For free upcoming tour information, go to http://www.pollstar.com

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20111122/ap_en_mu/us_top20_concert_tours

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Did Sex Emerge from Cannibalism? Sex, Death and Kefir, by Lynn Margulis (1938–2011)

Features | Evolution

Microorganisms trying to eat one another may have led to the symbiotic merger of their genes?and also started the process of aging


Image: Courtesy of the University of Massachusetts Amherst

Editor's note: This essay, by renowned evolutionary biologist Lynn Margulis, was published in the August 1994 issue of Scientific American with the title, "Sex, Death and Kefir." Margulis died on Tuesday in her home, according to a statement released by the University of Massachusetts at Amherst, where she was a Distinguished University Professor of Geosciences. She is best known for her work on how symbiosis led to the evolution of organelles, which were once independent organisms (she describes her theory in her August 1971 Scientific American article "Symbiosis and Evolution" (pdf), which you can read if your library has an institutional subscription. She was also a major contributor to the Gaia theory, which posits that Earth is a self-regulating complex system, and was once married to astronomer Carl Sagan.

Sex, Death and Kefir

The certainty of death was absent at the origin of life. Unlike humans and other mammals, many organisms do not age and die. The process of programmed, inevitable death evolved only after our symbiotic microbial ancestors, some two billion years ago, became sexual individuals.

Any organism can die because of circumstances beyond its control: the ambience grows too hot, a predator attacks, poison gas permeates. But programmed death happens independently of environmental action: cornstalks topple at the end of the season, or a healthy elephant succumbs at the end of a century. Monthly, in menstruating women, the dead cells of the uterine lining flow through the vagina. Each autumn in the deciduous trees and shrubs of the North Temperate Zone, rows of cells at the base of the leaf stem die.

Unlike animals and plants that grow from embryos and die on schedule, all bacteria and most other microorganisms remain eternally young. These other organisms are protoctists and fungi. Protoctists constitute a diverse group that includes our animal ancestors, as well as seaweeds, ciliates, slime molds, foraminifera, diatoms and many others. Like the fungi (yeasts, molds and mushrooms), protoctists are symbiotic aggregates of nucleated cells that reproduce by cell division. Protoctist and fungal individuals can grow and reproduce without any sexual partners.

But in some protoctists?those that became the ancestors of the fungi, plants and animals?our kind of sex, which involves mating and cell fusion by fertilization, first appeared. I propose that it did so as an accidental consequence of a desperate strategy for survival. Sex began when unfavorable seasonal changes in the environment caused our protoctist predecessors to engage in attempts at cannibalism that were only partially successful. The result was a monster bearing the cells and genes of at least two individuals (as does the fertilized egg today).

The return of more favorable environmental conditions selected for survival those monsters able to regain their simpler, normal identity. To do so, each had to slough off half or more of the "extra" cell remains. Death and the genes that caused death evolved. "Death genes" have now been isolated and their operation studied. Lawrence M. Schwartz, here at the University of Massachusetts, for example, can predict the demise of cells in a laboratory culture to within a few hours when he introduces DNA containing death genes.

Source: http://rss.sciam.com/click.phdo?i=b46517721e3a4e203f5340a9e23409b2

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Justin Moore Welcomes Daughter Kennedy Kaye

Daughter Kennedy Kaye arrived at 7:59 a.m. in Arkansas, weighing in at 7 lbs. and measuring 18? inches long.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/Uho2NV4zfZI/

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Wednesday, November 23, 2011

Army defectors escalate Syrian uprising

Attacks by army defectors are transforming the Syrian uprising into an armed insurgency that threatens to spiral into civil war. The Free Syrian Army holds no territory, appears largely disorganized and is up against a fiercely loyal and cohesive military that will stop at nothing to protect the regime.

Still, without foreign military intervention or significant cracks in President Bashar Assad's iron rule, the rebel group has emerged as the best hope for a growing number of protesters who have all but given up on peaceful resistance.

Story: New phase in uprising? Syrian rebels launch 1st attack in capital

"They are the real heroes of this revolution," said one anti-regime protester in the central city of Hama, the site of a massacre by Assad's father and predecessor in 1982 and a hotbed of resistance to the regime. "Everyone else has abandoned us."

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Like most Assad opponents who spoke to The Associated Press, he asked that his name not be used for fear the regime will retaliate against him or his family.

There are concerns the presence of an organized armed rebel group has given authorities a pretext to crack down even harder on dissent, pushing the country toward civil war. The sectarian divide in Syria, where members of Assad's minority Alawite sect rule over a Sunni Muslim majority and others, means an insurgency could escalate quickly.

The leader of the Free Syrian Army, breakaway air force colonel Riad al-Asaad, acknowledges nearly all the defectors under his command ? some 15,000 ? are low-level Sunni conscripts. The men are armed with rocket-propelled grenades, rifles and guns they took with them when they deserted, as well as light weapons they acquired on the black market, he says.

Credible threat
The FSA holds no territory in Syria and al-Asaad himself is based in Turkey, where thousands of Syrian refugees have taken shelter since the uprising began. Communications with defectors on the ground is one of the biggest challenges to the group's growth.

Still, the FSA is a credible threat to the Assad regime, said Riad Kahwaji, CEO of the Institute for Near East and Gulf Military Analysis in Beirut.

"We're talking about troops who know the enemy very well, because they were members of these forces," Kahwaji told The Associated Press. "They know them by name, their culture, their habits. They know all the secrets. They are a serious threat to the regime."

Why Syria?s revolution needs a Benghazi

The standing army in Syria is estimated to be about 250,000, but that figure is closer to 700,000 if one includes the reserves, Kahwaji said. The top brass and many members of the standing army belong to Assad's Alawite sect, but the reserves are mainly Sunni.

"If (the conflict) continues at this rate, you're going to have pure Alawite troops fighting Sunni troops," he said in a telephone interview.

FSA attacks have grown increasingly sophisticated in recent weeks, prompting worldwide alarm that the situation in Syria is spiraling out of control.

Russia's foreign minister compared an FSA attack last week on an air force intelligence compound outside Damascus to the beginning of a civil war, and U.S. Secretary of State Hillary Rodham Clinton said the Syrian defectors could fuel a civil war.

UK: Remain peacful
Britain's Foreign Secretary William Hague, who met with opposition members Monday, stressed that the uprising should remain peaceful.

"I've ... emphasized to them the importance of non-violent protest and the importance of retaining international support in this situation through non-violent protest," he said.

Although it remains unclear exactly how powerful the FSA is, the attacks appear to have grown in the past few weeks as its members carried out ambushes that have killed dozens of soldiers and security personnel.

Young and restless: Demographics fuel Mideast protests

Syria severely restricts the work of journalists but amateur videos posted online showed damaged and burned security vehicles in several areas of Syria.

"Win or Die," proclaims the slogan on the group's Facebook page, through which it disseminates information and claims responsibility for attacks.

In an interview with the AP last month, al-Asaad, who defected in July, called on more Syrians to join his ranks.

"We encourage our Alawite and Christian brothers to defect so we can liberate Syria and build our future together," he said in a telephone interview from his base in Turkey.

In heavily anti-regime areas of Syria, many Syrians have been sheltering defectors, protecting them from raiding security forces.

'Serious danger'
"The situation is in serious danger of spiraling beyond the regime's control," said David Hartwell, senior Middle East and North Africa analyst at IHS Jane's in London. He cited attacks by the defectors coupled with more weapons reportedly being smuggled into Syria.

But in an example of disorganization that could prove damaging to the group, al-Asaad on Monday retracted earlier claims that his followers had launched an unprecedented attack on Assad's Baath party headquarters inside the capital, Damascus ? an embarrassing turnaround for the movement.

Al-Asaad said in a video posted on the group's Facebook page Sunday evening that Assad's government was trying to tarnish the image of the revolution.

"We did not target the party building in Damascus and we will not target any civilian installation," said the FSA commander, who was wearing his military uniform.

Still, he did not address why his group had claimed responsibility for such an attack after Damascus residents reported hearing two loud blasts before dawn Sunday. In a Facebook posting ? which had been removed by Monday morning ? the FSA said it fired rocket-propelled grenades at the ruling party headquarters.

The group disseminates information through its Twitter and Facebook page, which includes a bank account number in Turkey for those wishing to support the revolution.

Al-Asaad, a soft spoken, mustachioed man, brands his group as "the voice of the Syrian people." But he acknowledges it is up against a major challenge.

Unlike the armies of Tunisia and Egypt, Syria's military has stood fiercely by the country's leader as Assad faces down an extraordinary protest movement.

Assad, and his father before him, stacked key military posts with members of their minority Alawite sect over the past 40 years, ensuring the loyalty of the armed forces by melding the fate of the army and the regime.

International intervention, such as the NATO action in Libya that helped topple Moammar Gadhafi, is all but out of the question in Syria. There also is real concern that Assad's ouster would spread chaos around the region.

Without external help, the group will find it extremely hard to claim a slice of Syrian territory like the anti-Gadhafi fighters in their de facto capital Benghazi.

In an interview with Al-Jazeera this week, Al-Asaad said his goal is to have the Syrian army crumble from within.

"They have tanks and airplanes, but they fear us with our small weapons," he said. "We have the Syrian people behind us. This is our strength."

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/45390188/ns/world_news-mideast_n_africa/

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Compal Communications handset shipments increasing, says paper

Taiwan ICT industry development and outlook

A presentation prepared for Taiwan Ministry of Economic Affairs (MOEA), offering an overview of Taiwan's key ICT industries and the dynamics influencing future development. The report is free for download.

Standards and scale of Asia LED lighting markets

Digitimes Research projects marked growth in LED markets across Asia over the next five years. This Digitimes Research Special Report provides an overview of the standards in the major LED lighting markets in Asia.

Source: http://www.digitimes.com/news/a20111122PB201.html

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Visa program for Afghan allies comes up empty (reuters)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/165059118?client_source=feed&format=rss

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Tuesday, November 22, 2011

When it comes to churning out electrons, metal glass beats plastics

ScienceDaily (Nov. 21, 2011) ? Field emission devices, which produce a steady stream of electrons, have a host of consumer, industrial, and research applications. Recent designs based on nanotubes and other nanomaterials embedded in plastics show initial promise, but have a number of drawbacks that hinder their wide-scale application.

The embedded nanotubes, which serve as the source for the electrons, also enable the normally inert plastic to conduct electricity. This has the desired effect of producing a versatile and easily manufactured field emission device. But since plastics are, by nature, poor conductors of electricity, they require a high concentration of nanomaterials to function. Plastics also have low thermal stability and do not hold up well under the excess heat produced by prolonged operation.

A team of researchers from Monash University in Australia, in collaboration with colleagues from CSIRO Process Science and Engineering, has developed a promising and easily manufactured replacement for plastics: amorphous bulk metallic glass (ABM). These ABM alloys form amorphous materials as they cool, giving them more of a glass-like behavior. In a paper accepted for publication in the AIP's journal Applied Physics Letters, the researchers used an alloy made from magnesium, copper, and gadolinium.

This metallic glass has many of plastics' desirable features. It can conform to a variety of shapes, be produced in bulk, and serve as an effective matrix for the nanotubes. Besides its high conductivity, the metallic glass' highly robust thermal properties mean that it can withstand high temperatures and still retain its shape and durability. According to the researchers, these advantages, alongside excellent electron emission properties, make these composites one of the best reported options for electron emission applications to date.

Though other composites of bulk metallic glass and carbon nanotubes have been reported before, this is the first time that such a system is being used for a functional device, such as for field emission. Electron microscopes, microwave or X-ray generation, nano-electronics, and modern display devices are all examples of the potential applications of this technology, the researchers note.

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The above story is reprinted from materials provided by American Institute of Physics.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Pejman Hojati-Talemi, Mark A. Gibson, Daniel East, George P. Simon. High performance bulk metallic glass/carbon nanotube composite cathodes for electron field emission. Applied Physics Letters, 2011; 99 (19): 194104 DOI: 10.1063/1.3659898

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/11/111121104155.htm

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New class of small molecules discovered through innovative chemistry

ScienceDaily (Nov. 20, 2011) ? Inspired by natural products, scientists on the Florida campus of The Scripps Research Institute have created a new class of small molecules with the potential to serve as a rich foundation for drug discovery.

Combining the power of synthetic chemistry with some advanced screening technologies, the new approach could eventually expand by millions the number of provocative synthetic compounds available to explore as potential drug candidates. This approach overcomes substantial molecular limitations associated with state-of-the-art approaches in small molecule synthesis and screening, which often serve as the foundation of current drug discovery efforts.

The study, led by Scripps Research Associate Professor Glenn Micalizio, was published November 20, 2011, in an advanced online edition of the journal Nature Chemistry.

To frame the significance of this advance, Micalizio explains that high-throughput screening is an important component of modern drug discovery. In high-throughput screening, diverse collections of molecules are evaluated en masse for potential function in a biological area of interest. In this process, success is critically dependent on the composition of the molecular collections under evaluation. Modern screening centers maintain a relatively static collection of molecules, the majority of which are commercially available materials that have structures unrelated to natural products -- molecules that are appreciated as validated leads for drug development.

"This divergence in structure between natural products and commercially available synthetics lies at the heart of our inquiry," said Micalizio. "Why should we limit discovery of therapeutic leads to compound collections that are influenced by concerns relating to commercial availability and compatibility with an artificial set of constraints associated with the structure of modern screening centers?"

To expand the compounds available for investigation, the scientists embraced an approach to structural diversity that mimics nature's engine for the discovery of molecules with biological function. This process, termed "oligomerization," is a modular means of assembling structures (akin to the way that letters are used in a sequence to provide words with meaning) where a small collection of monomeric units can deliver a vast collection of oligomeric products of varying length, structure, and function (like the diversity of words presented in a dictionary).

Coupling this technique with a synthetic design aimed at generating molecules that boast molecular features inspired by the structures of bioactive natural products (specifically, polyketide-derived natural products, which include erythromycin, FK-506, and epothilone), the scientists established a new chemical platform for the discovery of potential therapeutics.

Micalizio points out: "The importance of oligomerization to drive discovery is well appreciated in chemistry and biology, yet a means to realize this process as an entry to small molecule natural product-inspired structures has remained elusive. The crux of the problem is related to challenges associated with the control of shape for each member of a complex oligomer collection -- the central molecular feature that defines biological function."

"It is the stability associated with the shape of these new compounds that lies at the heart of the practical advance," he continued. "The unique features of this science now make possible the ability to synthesize large collections of diverse natural product-inspired structures that have predictable and stable three-dimensional shapes."

Micalizio said that the science described represents a first step toward revolutionizing discovery at the interface of chemistry, biology, and medicine by embracing nature's strategy for molecular discovery. Coupling this type of advance with modern screening technology that can handle the evaluation of large compound collections at low cost (such as work by Scripps Florida Professor Thomas Kodadek, a co-author of the new study), can dramatically enhance the future of pharmaceutically relevant science.

The potential of this vision was highlighted in the new study, in which a 160,000-member compound collection was employed to discover the first non-covalent small molecule ligand to the DNA binding domain of p53 -- an important transcription factor that regulates a variety of genes involved in cell cycle control and cell death.

The first author of the study, "A Biomimetic Polyketide-Inspired Approach to Small-Molecule Ligand Discovery," is Claudio Aquino of Scripps Research. In addition to Micalizio and Kodadek, other authors include Mohosin Sarkar, Michael J. Chalmers, and Kimberly Mendes.

The study was supported by the Fidelity Biosciences Research Initiative, The State of Florida (The Florida Funding Corporation), and the National Institutes of Health.

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The above story is reprinted from materials provided by The Scripps Research Institute, via AlphaGalileo.

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Journal Reference:

  1. Claudio Aquino, Mohosin Sarkar, Michael J. Chalmers, Kimberly Mendes, Thomas Kodadek, Glenn C. Micalizio. A biomimetic polyketide-inspired approach to small-molecule ligand discovery. Nature Chemistry, 2011; DOI: 10.1038/nchem.1200

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/11/111120134706.htm

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